I use it and love it, never used Poker Tracker though
its fairly easy to use and they are adding more sites all the time

the one thing that sucks is you have to pretty much use player made guides and advice on Poker Tracker if you are unfamiliar with this type of program for help as they are similiar, and most people use Poker tracker. Also the Poker Tracker site has much better peer support compared to poker office, although the poker office site administrators will help you with your questions, its just sad the other users dont help much in the PO site forum.
hope this made sense, think my brain is tired from playiong too much poker lol